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26 Feb 2014
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AltebrelTM, is biosimilar product with the generic name of Etanercept. It uses for treatment of several autoimmune diseases like Rheumatoid Arthritis, Plaque Psoriasis, Psoriasis Arthritis, Spondylarthritis, Ankylosing Spondilities and Juvenile Idiopathic.
Etanercept is a fusion protein consisting from a FC part of antibodies and two TNF receptor. Etanercept is a homodimeric protein. Each monomer is composed of an extra cellular receptor part which is banded to human TNFα with Fc part of immunoglobulin IgG1.
Etanercept manufacturing is based on expression by a protein recombinant technology using Chinese Hamster Ovary (CHO) cell. This molecule is composed of 934 amino acids with weight of 150 KDa and acts as a TNFα Blocker. TNFα is a kind of cytokines which is produced by monocytes and macrophages and increases white cells flow to the site of inflammation. According to this function beside some other related mechanisms, TNFα could increase inflammation. So, Etanercept decreases inflammation responses through inhibiting the mentioned TNFα mechanism which is completely effective in treatment of autoimmune diseases.
This medicine is produced as prefilled syringe containing solution form with two different dosages: 25 mg and 50 mg. For more information visit us at www.altebrel.com
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